A few years back I pointed out a charitable endeavor from the guys at Penny Arcade: Childs Play.
The guys have put together a site where various children's hospitals around the world can put together an Amazon wish list, and you can buy needed toys for kids who have extended stays at the various hospitals.
When I last pointed this site out, Cincinnati didn't have a presence on the charity list, but now they do. So The Girl and I are going to forgo any serious gifts for each other (small knick knacks in the $20 range only) and instead give what we would normally spend on each other.
If you have a few bucks, you might want to consider checking out one of the hospitals in your area. Heaven knows that the kids are in need and that most of us have a little that we can send their way.
Or you can help children even less fortunate through the One Laptop program.